Extracellular Matrices and Basement Membrane Extracts

Substrates that mimic the extracellular matrix (ECM) in culture have been shown to be imperative for robust cell growth, optimal health, and as a method to direct the behavior and structural formation of cells in vitro. Basement membrane extract (BME) is a commonly used scaffolding for 2- and 3-D cell culture, including pluripotent stem cell expansion and differentiation as well as spheroid and organoid formation. BMEs contain laminin, fibronectin, collagen IV, vitronectin, entactin, and heparan sulfate proteoglycans. This mixture of ECM proteins within the hydrogel plays an important role in directing cell behavior and health, providing not only a critical growth substrate but also an optimized environment for cell-to-cell interactions to facilitate in vivo-like growth dynamics. While BME is being utilized across a wide breath of applications, the quality and behavior of cells cultured in BME can greatly be impacted by handling, hydrogel concentration, and coating methods.

 

Choose the Best Cell Matrices for Your Research

Cultrex matrices are carefully formulated to mimic the complex composition and physical properties of the native ECM, providing a more physiologically relevant environment for your cells to grow and function in. By using Cultrex, you can more accurately replicate the in vivo microenvironment and achieve more reliable and meaningful results. Cultrex is rigorously tested for quality and consistency, ensuring that you get the same reliable results every time.

 

As a leading brand in the development and production of high-quality cell matrices, our extensive range of Cultrex ECM products is designed to meet the specific needs of a diverse range of fields, including cancer biology, stem cell research, and tissue engineering.

 

See the selection guide below to purchase today or reach out to a specialist to discuss how we can provide a reliable source of ECM for your research or help you find the right matrix.

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