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Spheroids vs. Organoids: Which 3D Cell Culture Model is Best for You?

Spheroids: The Original 3D Cell Culture First developed in the 1970s, spheroids are generated from primary cells or cancer cell lines that self-assemble into simple, spherical cell aggregates.1-3,5,6 Spheroid culturing is relatively simple and can be done with or without extracellular matrix (ECM) support.2,3,6 There are now a number of different spheroid culture models and methods including the hanging-drop method, ultra-low attachment plates, hydrogels, rotary cell cultures, microfluidics systems, and bioprinting.

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